منابع مشابه
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kinase better known for triggering DNA replication also helps create the sticky heterochromatin at centromeres of fission yeast, according to Julie Bailis, Susan Forsburg (Salk Institute, La Jolla, CA), and colleagues. The dual action makes sense, as chromosomes must be stuck together as soon as they are replicated. The responsible kinase activity, Hsk1 (CDC7)–Dfp1, is restricted to S phase, wh...
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RIG-I and MDA5 are cytoplasmic RNA sensors that recognize dsRNA patterns and activate MAVS to induce innate antiviral gene program. RNA sensing is regulated by ubiquitination in RIG-I while by phosphorylation in MDA5. Thus, de novo phosphorylation is an essential step for keeping MDA5 inactive. We identified a protein kinase RIO kinase 3 (RIOK3) targeting MDA5, and here discuss its possible rel...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/541252a